From Encyclopedia of Medicinal Plants
Template:Italic titleTemplate:Taxobox Chelidonium majus, commonly known as greater celandine or tetterwort,<ref>Template:Cite journal</ref>(although tetterwort also refers to Sanguinaria canadensis), nipplewort,<ref name=GRIN>Template:Cite web</ref> or swallowwort,<ref name=GRIN/> is a herbaceous perennial plant, the only species in the genus Chelidonium. It is native to Europe and western Asia and introduced widely in North America.
Taxonomy and naming
The greater celandine is one of the many species described by the father of taxonomy, Carl Linnaeus, in volume one of his Species Plantarum in 1753.<ref>Template:Cite book</ref> According to the Oxford English Dictionary, celandine comes from Late Latin celidonia, from earlier Latin chelidonia or chelidonium, and ultimately from Ancient Greek Template:Lang, from Template:Lang (Template:Unicode) "swallow". Ancient writers said that the flower bloomed when the swallows returned and faded when they left.<ref>Template:Cite web</ref>
Greater celandine is a perennial herb with an erect habit, and reaches 30 to 120 cm high. The leaves are pinnate with lobed and wavy-edged margins, up to 30 cm long. When injured, the plant exudes a yellow to orange latex.
The flowers consist of four yellow petals, each about 1 cm long, with two sepals. A double-flowered variety occurs naturally. The flowers appear from late spring to summer in umbelliform cymes of about 4 flowers.
It is considered an aggressive invasive plant in natural areas.<ref>Template:Cite web</ref> Control is obtained mainly via pulling or spraying the plant before seed dispersal.
The whole plant is toxic in moderate doses as it contains a range of isoquinoline alkaloids but there are numerous therapeutic uses when used at the correct dosage.<ref name='PDR'>Template:Cite book</ref> The main alkaloid present in the herb and root is coptisine. Other alkaloids present include methyl 2'-(7,8-dihydrosanguinarine-8-yl)acetate, allocryptopine,<ref>Cahlikova L., Opletal L., Kurfurst M., Macakova K., Kulhankova A., Host'alkova A.,"Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae)." Natural Product Communications. 5 (11) (pp 1751-1754), 2010. Date of Publication: 2010.</ref> stylopine, protopine, norchelidonine, berberine, chelidonine, sanguinarine, chelerythrine,<ref>Li X.-L., Yao J.-Y., Zhou Z.-M., Shen J.-Y., Ru H.-S., Liu X.-L.,"Activity of the chelerythrine, a quaternary benzo[c]phenanthridine alkaloid from Chelidonium majus L. on Dactylogyrus intermedius." Parasitology Research. 109 (1) (pp 247-252),July 2011</ref> and 8-hydroxydihydrosanguinarine.<ref>Park J.E., Cuong T.D., Hung T.M., Lee I., Na M., Kim J.C., Ryoo S., Lee J.H., Choi J.S., Woo M.H., Min B.S.,"Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells". Bioorganic and Medicinal Chemistry Letters. 21 (23) (pp 6960-6963), 2011. Date of Publication: 01 Dec 2011.</ref> Sanguinarine is particularly toxic with an Template:LD50 of 18 mg per kg body weight (IP in rats).<ref>Template:Cite book</ref> Caffeic acid derivatives, such as caffeoylmalic acid, are also present.<ref>Hydroxycinnamic Acid Derivatives, Caffeoylmalic and New Caffeoylaldonic Acid Esters, from Chelidonium majus. Hahn R and Nahrstedt A, Planta Med., February 1993, volume 59, issue 1, pages 71-75, Template:PMID</ref>
Some alkaloids have shown potential activity against methicillin-resistant Staphylococcus aureus.<ref>Zuo G.Y., Meng F.Y., Hao X.Y., Zhang Y.L., Wang G.C., Xu G.L."Antibacterial alkaloids from chelidonium majus linn (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus." Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 11 (4) (pp 90-94), 2008.</ref>
The effect of the fresh herb is of a mild analgesic, cholagogic, antimicrobial, oncostatic and central nervous system sedative.<ref>European Medicines Agency. Assessment report on Chelidonium majus L., herba. Date of Publication: 20/01/2012. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2012/01/WC500120711.pdf</ref> In in vitro experiments on animal cells celandine is shown to be cytostatic.<ref>Template:Cite journal</ref> An immune stimulating effect has also been noted.Template:Citation needed Some studies show that the alkaloid extraction can have the same effects. The alkaloids are known to cause immobilization in mice after being ingested orally or injected. The alkaloids cause limpness and tone reduction of smooth muscle in rabbits. The alkaloids are also noted to stimulate the heart and lungs of frogs, cats and dogs, raising the blood pressure and widening the arteries.Template:Citation needed
The latex could be employed for cauterizing small open wounds.Template:Citation needed Early studies of celandine showed that it causes contact dermatitis and eye irritation, particularly from contact with the poisonous red to yellow latex of the stem. This effect has not been observed in animal studies; no inflammation was observed in rabbit eye tests. The latex can leave a non-permanent stain. Stains on skin of the fingers are sometimes reported to cause eye irritation after rubbing the eyes or handling contact lenses. The latex is also known to stain clothes.
The characteristic latex also contains proteolytic enzymes and the phytocystatin chelidostatin, a cysteine protease inhibitor.<ref>Template:Cite journal</ref> These co-constituents could explain the topical use of greater celandine against warts and moles.
"Ukrain" (Template:Lang-uk) is an alternative medicine promoted to treat cancer based on chelidonium. The drug was created in 1978 by the Ukrainian chemist Vasyl Novytskyi. The drug is named in honor of the nation of Ukraine and is produced by an Austrian company Nowicky Pharma.<ref>The official site about the drug Ukrain</ref> Although the drug was never approved by any regulators, Novytskyi claimed it to be a complete cure for all cancers, radiation-induced diseases and AIDS and was arrested in Vienna for aggravated fraud on September 4, 2012.<ref>Allheilmittel gegen Aids und Krebs: Zwei Verhaftungen wegen Betrugs in Wien, Der Standard, 4 Sept. 2012</ref>
C. majus has shown analgesic activity at 200 mg/kg dose in mice.<ref>Sever Yilmaz B., Ozbek H., Saltan Citoglu G., Ugras S., Bayram I., Erdogan E."Analgesic and hepatoprotective effects of Chelidonium majus" L.. Ankara Universitesi Eczacilik Fakultesi Dergisi. 36 (1) (pp 9-20), 2007.</ref>
The aerial parts and roots of greater celandine are used in herbalism. The above-ground parts are gathered during the flowering season and dried at high temperatures. The root is harvested in autumn between August and October and dried. The fresh rhizome is also used. Celandine has a hot and bitter taste. Preparations are made from alcoholic and hot aqueous extractions (tea). The related plant bloodroot has similar chemical composition and uses as greater celandine.
As far back as Pliny the Elder and Dioscorides (1st century CE) this herb has been recognized as a useful detoxifying agent. The root has been chewed to relieve toothache.<ref>Template:Cite book</ref> John Gerard's Herball (1597) states that "the juice of the herbe is good to sharpen the sight, for it cleanseth and consumeth away slimie things that cleave about the ball of the eye and hinder the sight and especially being boiled with honey in a brasen vessell."<ref>Template:Cite book</ref>
It was formerly used by gypsies as a foot refresher; modern herbalists use its purgative properties.<ref>Template:Cite book</ref> Juliette de Baïracli Levy, the Jewish-English herbalist, recommended greater celandine for the eyes, diluted with milk, and the latex to be used for getting rid of warts.<ref>Bailes M., "The Healing Garden" , ISBN 978-0-7318-0753-6</ref> Chelidonium was a favourite herb of the French herbalist Maurice Mességué. Chelidonium majus has traditionally been used for treatment of various inflammatory diseases including atopic dermatitis.<ref>Template:Cite journal</ref> It is also traditionally used in the treatment of gallstones and dyspepsia.<ref>Template:Cite journal</ref>
The Iroquois give an infusion of whole plant, another plant & milk to pigs that drool and have sudden movements.<ref>Rousseau, Jacques 1945 Le Folklore Botanique De Caughnawaga. Contributions de l'Institut botanique l'Universite de Montreal 55:7-72 (p. 45)</ref>
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